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H60466 4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate, 95%

CAS Number
80149-80-0
Synonyms
Carbonic acid 4-nitrophenyl 2-(trimethylsilyl)ethyl ester
Teoc-ONp

Stock No. Size Price ($) Quantity Availability
H60466-03 1g 50.60
H60466-06 5g 199.00
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4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate, 95%

MDL
MFCD00042930
EINECS
279-406-7

Chemical Properties

Formula
C12H17NO5Si
Formula Weight
283.35
Melting point
35-40°
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Light Sensitive. Store under Nitrogen.
Solubility
Slightly soluble in water.

Applications

It is employed as a reagent for the introduction of the TEOC-amino protecting group which can be cleaved by F-.

Notes

Moisture & Light Sensitive. Store at 2-8°C.

Literature References

Andre Rosowsky.; Joel E. Wright. N.µ.-Alkoxycarbonylation of .alpha.,.µ.-diamino acids with 2-(trimethylsilyl)ethyl 4-nitrophenyl carbonate. J. Org. Chem. 1983, 48 (9), 1539-1541.

Takamasa Iimori.; Takafumi Shibazaki.; Shiro Ikegami. A novel intramolecular decarboxylative glycosylation via mixed carbonate. Tetrahedron Lett. 1996, 37 (13),2267-2270.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
4320585
Harmonized Tariff Code
2931.90
TSCA
No

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