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112529-15-4 - Pioglitazone hydrochloride, 98% - 5-(4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl)thiazolidine-2,4-dione hydrochloride - H60507 - Alfa Aesar

H60507 Pioglitazone hydrochloride, 98%

CAS Number
112529-15-4
Synonyms
5-(4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl)thiazolidine-2,4-dione hydrochloride

Size Price ($) Quantity Availability
250mg 40.17
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Pioglitazone hydrochloride, 98%

MDL
MFCD04975446

Chemical Properties

Formula
C19H20N2O3S•HCl
Formula Weight
392.90
Solubility
Soluble in water (<1 mg/ml at 25°C), DMF, methanol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C).

Applications

Pioglitazone hydrochloride exhibits antiinflammatory and antiarteriosclerotic effects. It is used to prevent L-NAME-induced coronary inflammation and arteriosclerosis and to suppress increased TNF-&#945; mRNA produced by aspirin-induced gastric mucosal injury. Pioglitazone Hydrochloride is an activator of PPAR &#947;. It is a PPAR&#947; agonist and thiazolidinedione (TZD) anti-diabetic. Pioglitazone is a selective agonist of the nuclear receptor peroxisome proliferator-activated receptor &#947; (PPAR-&#947;) and to a lesser extent PPAR-&#945;.

Notes

Store in a cool, dry conditions in a well sealed container. Store away from oxidizing agents.

Literature References

S Kersten; B Desvergne; W Wahli. Roles of PPARs in health and disease. Nature.2000, 405 (6785), 421-424.

Klemens Budde; Hans-Hellmut Neumayer; Lutz Fritsche; Wladyslaw Sulowicz; Tomasz Stompôr; David Eckland. The pharmacokinetics of pioglitazone in patients with impaired renal function. British Journal of Clinical Pharmacology.2003, 55 (4), 368-374.

GHS Hazard and Precautionary Statements

Hazard Statements: H319

Causes serious eye irritation.

Precautionary Statements: P280-P264-P305+P351+P338-P337+P313

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

Other References

Harmonized Tariff Code
2934.10
TSCA
No
RTECS
XJ5813440

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