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H60613 4-(4-Methoxyphenyl)butyric acid, 98%

CAS Number
4521-28-2
Synonyms

Stock No. Size Price ($) Quantity Availability
H60613-03 1g 15.30
H60613-06 5g 60.90
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4-(4-Methoxyphenyl)butyric acid, 98%

MDL
MFCD00004404
EINECS
224-849-3

Chemical Properties

Formula
C11H14O3
Formula Weight
194.23
Melting point
56-59°
Storage & Sensitivity
Ambient temperatures.
Solubility
Slightly soluble in methanol. Insoluble in chloroform.

Applications

4-(4-Methoxyphenyl)butyric acid on demethylation with pyridinium hydrochloride affords 4-hydroxyphenylbutyric acid, a key starting material for the synthesis of preclinical candidate LY518674.

Notes

Store in a cool, dry place, in a well sealed container. Store away from oxidizing agents.

Literature References

Christopher R. Schmid; Christopher A. Beck; Jason S. Cronin and Michael A. Staszak. Demethylation of 4-Methoxyphenylbutyric Acid Using Molten Pyridinium Hydrochloride on Multikilogram Scale. Org. Proc. Res. Dev. 2004, 8 (4), 670-673.

Timothy P. Kogan; Brian Dupré, Huong Bui; Kathy L. McAbee; Jamal M. Kassir; Ian L. Scott; Xin Hu; Peter Vanderslice; Pamela J. Beck and Richard A. F. Dixon. Novel Synthetic Inhibitors of Selectin-Mediated Cell Adhesion:? Synthesis of 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2-α-d-mannopyranosyloxy)phenyl]hexane (TBC1269). J. Med. Chem. 1998, 41 (7), 1099-1111.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2416568
Harmonized Tariff Code
2918.99
TSCA
No

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