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2-Hydroxy-3-methylbutyric acid is employed as internal standard for analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood.
E. Campo.; J. Cacho.; V. Ferreira. Multidimensional chromatographic approach applied to the identification of novel aroma compounds in wine: Identification of ethyl cyclohexanoate, ethyl 2-hydroxy-3-methylbutyrate and ethyl 2-hydroxy-4-methylpentanoate. Journal of Chromatography A. 2006, 1137 (2), 223-230.
Yan-Song Zheng.; Chun Zhang. Exceptional Chiral Recognition of Racemic Carboxylic Acids by Calixarenes Bearing Optically Pure α,β-Amino Alcohol Groupsd. Org. Lett. 2004, 6 (8), 1189-1192.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.