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59557-91-4 - 4-Bromo-2-methoxyaniline, 98% - H61454 - Alfa Aesar

H61454 4-Bromo-2-methoxyaniline, 98%

CAS Number
59557-91-4
Synonyms

Size Price ($) Quantity Availability
1g 24.30
5g 109.00
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4-Bromo-2-methoxyaniline, 98%

MDL
MFCD01204266

Chemical Properties

Formula
C7H8BrNO
Formula Weight
202.05
Solubility
Soluble in methanol.

Applications

4-Bromo-2-methoxyaniline is used as a reagent in the synthesis of 3,5-diamino-1,2,4-triazole ureas as potent anaplastic lymphoma kinase (ALK) inhibitors. It is also used as a reagent in the synthesis of chroman-3-amides as potent Rho kinase inhibitors. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literature References

P. S. Portoghese.; H. Nagase.; A. W. Lipkowski.; D. L. Larson.; A. E. Takemori. Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity [Erratum to document cited in CA108(17):150771q]. J. Med. Chem. 1988, 31 (10), 2056-2056.

Kate M. Clapham.; Julia Bardos.; M. Raymond V. Finlay.; Bernard T. Golding.; Edward J. Griffen.; Roger J. Griffin.; Ian R. Hardcastle.; Keith A. Menear.; Attilla Ting.; Paul Turner.; Gail L. Young.; Celine Cano. DNA-dependent protein kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (3), 966-970.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H331-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P311a-P301+P312a-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.29
TSCA
No

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