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5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban.
Uroš Trstenjak; Janez Ilaš; and Danijel Kikelj. Spoerri. Transformation of a selective factor Xa inhibitor rivaroxaban into a dual factor Xa/thrombin inhibitor by modification of the morpholin-3-one moiety. Med. Chem. Commun. 2014, 5197-202.
Li, Chao; Liu, Yingshuai; Zhang, Yongjun; Zhang, Xingxian. Spoerri. An approach to the anticoagulant agent rivaroxaban via an isocyanate-oxirane cycloaddition promoted by MgI2.etherate. Journal of Chemical Research. 2011, 35400-401(2).
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.