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H61474 5-Chlorothiophene-2-carbonyl chloride, 98%

CAS Number
42518-98-9
Synonyms

Stock No. Size Price ($) Quantity Availability
H61474-06 5g 137.00
H61474-14 25g 548.00
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5-Chlorothiophene-2-carbonyl chloride, 98%

MDL
MFCD00043886

Chemical Properties

Formula
C5H2Cl2OS
Formula Weight
181.04
Melting point
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Store under Nitrogen.
Solubility
Slightly soluble in water.

Applications

5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban.

Notes

Moisture Sensitive. Store in cool, dry place in tightly closed container. Store away form water/moisture.

Literature References

Uroš Trstenjak; Janez Ilaš; and Danijel Kikelj. Spoerri. Transformation of a selective factor Xa inhibitor rivaroxaban into a dual factor Xa/thrombin inhibitor by modification of the morpholin-3-one moiety. Med. Chem. Commun. 2014, 5197-202.

Li, Chao; Liu, Yingshuai; Zhang, Yongjun; Zhang, Xingxian. Spoerri. An approach to the anticoagulant agent rivaroxaban via an isocyanate-oxirane cycloaddition promoted by MgI2.etherate. Journal of Chemical Research. 2011, 35400-401(2).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2934.99
TSCA
No

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