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2,2,2-Trifluoroethyl trifluoromethanesulfonate is a powerful trifluoroethylating agent which is useful for synthesis of fluorinated amino acids. It is used as a reagent in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines.
Laura A.McAllister; Bruce M.Bechle; Amy B.Dounay; Edelweiss Evrard; Xinmin Gan; Somraj Ghosh; Ji-Young Kim; Vinod D.Parikh; Jamison B.Tuttle; Patrick R.Verhoest. A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction. Journal of Organic Chemistry. 2011, 76,(9), 3484-3497.
Junji Ichikawa; Hideharu Jyono; Satoshi Yonemaru; Tatsuo Okauchi; Toru Minami. A facile synthesis of 1-H-2,2-difluorovinylphosphorus compounds from 2,2,2-trifluoroethyl trifluoromethanesulfonate and substitutions of their vinylic fluorines. Journal of Fluorine Chemistry. 1999, 97,(1-2), 109-114.
Hazard Statements: H302-H312-H314-H332-H335
Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. Harmful if inhaled. May cause respiratory irritation.
Precautionary Statements: P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant