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6226-25-1 - 2,2,2-Trifluoroethyl trifluoromethanesulfonate, 95% - Trifluoromethanesulfonic acid 2,2,2-trifluoroethyl ester - H61603 - Alfa Aesar

H61603 2,2,2-Trifluoroethyl trifluoromethanesulfonate, 95%

CAS Number
6226-25-1
Synonyms
Trifluoromethanesulfonic acid 2,2,2-trifluoroethyl ester

Size Price ($) Quantity Availability
5g 136.99
25g 477.60
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2,2,2-Trifluoroethyl trifluoromethanesulfonate, 95%

MDL
MFCD00671579

Chemical Properties

Formula
C3H2F6O3S
Formula Weight
232.10
Flash Point
>110°(230°F)
Density
1.611
Refractive Index
1.3060
Sensitivity
Moisture Sensitive
Solubility
Slightly soluble in water.

Applications

2,2,2-Trifluoroethyl trifluoromethanesulfonate is a powerful trifluoroethylating agent which is useful for synthesis of fluorinated amino acids. It is used as a reagent in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines.

Notes

Moisture sensitive. Incompatible with oxidizing agents and heat.

Literature References

Laura A.McAllister; Bruce M.Bechle; Amy B.Dounay; Edelweiss Evrard; Xinmin Gan; Somraj Ghosh; Ji-Young Kim; Vinod D.Parikh; Jamison B.Tuttle; Patrick R.Verhoest. A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction. Journal of Organic Chemistry. 2011, 76,(9), 3484-3497.

 

Junji Ichikawa; Hideharu Jyono; Satoshi Yonemaru; Tatsuo Okauchi; Toru Minami. A facile synthesis of 1-H-2,2-difluorovinylphosphorus compounds from 2,2,2-trifluoroethyl trifluoromethanesulfonate and substitutions of their vinylic fluorines. Journal of Fluorine Chemistry. 1999, 97,(1-2), 109-114.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H332

Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if inhaled.

Precautionary Statements: P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2905.59
TSCA
No
RTECS
PB2775000

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