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2971-79-1 - Methyl piperidine-4-carboxylate, 98% - Piperidine-4-carboxylic acid methyl ester - Methyl isonipecotate - H61754 - Alfa Aesar

H61754 Methyl piperidine-4-carboxylate, 98%

CAS Number
2971-79-1
Synonyms
Piperidine-4-carboxylic acid methyl ester
Methyl isonipecotate

Size Price ($) Quantity Availability
25g 33.10
100g 108.00
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Methyl piperidine-4-carboxylate, 98%

MDL
MFCD00190578

Chemical Properties

Formula
C7H13NO2
Formula Weight
143.18
Boiling Point
85-90°
Flash Point
89°(192°F)
Density
1.06
Refractive Index
1.4650
Solubility
Slightly soluble in water.

Applications

Methyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Hana Prokopcova; Sheba D.Bergman; Karel Aelvoet; Veerle Smout; Wouter Herrebout; Benjamin Van der Veken; Lieven Meerpoel; Bert U.W.Maes. C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation. Chemistry: A European Journal. 2010, 16,(44), 13063-13067.

 

Ahmed Kamal; Rajesh V.C.R.N.C. Shetti; Shaik Azeeza; S.Kaleem Ahmed; P.Swapna; A.Malla Reddy; Inshad Ali Khan; Sandeep Sharma; Sheikh Tasduq Abdullah. Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. European Journal of Medicinal Chemistry. 2010, 45,(10), 4545-4553.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260-P201-P280a-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
224128
Harmonized Tariff Code
2933.39
TSCA
No

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