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Tri(1-aziridinyl)phosphine sulfide is useful for the treatment of cancers, especially cancers resistant to chemotherapy. Antineoplastic. Thio-TEPA (N,NN-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to hematopoietic progenitor cell transplantation (HPCT)
Craig Knox et. al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Research. 2011, 39(3), D1035-D1041.
A J Wyrobek; and W R Bruce. Chemical induction of sperm abnormalities in mice. Proceedings of the National Academy of Sciences of the United States of America. 1975, 72(11), 4425-4429.
Hazard Statements: H300-H340-H350
Fatal if swallowed. May cause genetic defects. May cause cancer.
Precautionary Statements: P201-P280-P301+P310a-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.