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52-24-4 - Tri(1-aziridinyl)phosphine sulfide, 98% - Triethylenethiophosphoramide - Thio-TEPA - H61778 - Alfa Aesar

H61778 Tri(1-aziridinyl)phosphine sulfide, 98%

CAS Number
52-24-4
Synonyms
Triethylenethiophosphoramide
Thio-TEPA

Size Price ($) Quantity Availability
1g 102.00
5g 470.00
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Tri(1-aziridinyl)phosphine sulfide, 98%

MDL
MFCD00145452
EINECS
200-135-7

Chemical Properties

Formula
C6H12N3PS
Formula Weight
189.22
Solubility
Soluble in benzene, acetone and methanol.

Applications

Tri(1-aziridinyl)phosphine sulfide is useful for the treatment of cancers, especially cancers resistant to chemotherapy. Antineoplastic. Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to hematopoietic progenitor cell transplantation (HPCT)

Notes

Store in cool, well ventilated area. Keep container tightly closed. Store away from oxidizing agent.

Literature References

Craig Knox et. al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Research. 2011, 39(3), D1035-D1041.

A J Wyrobek; and W R Bruce. Chemical induction of sperm abnormalities in mice. Proceedings of the National Academy of Sciences of the United States of America. 1975, 72(11), 4425-4429.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H340-H350

Fatal if swallowed. May cause genetic defects. May cause cancer.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
SZ2975000

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