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239074-29-4 - trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane, 97% - tert-Butyl trans-(4-hydroxymethyl)cyclohexylcarbamate - trans-4-(Boc-amino)cyclohexanemethanol - H62487 - Alfa Aesar

H62487 trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane, 97%

CAS Number
239074-29-4
Synonyms
tert-Butyl trans-(4-hydroxymethyl)cyclohexylcarbamate
trans-4-(Boc-amino)cyclohexanemethanol

Size Price ($) Quantity Availability
1g 65.30
5g 245.00
25g 979.00
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trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane, 97%

MDL
MFCD03844605

Chemical Properties

Formula
C12H23NO3
Formula Weight
229.31
Solubility
Slightly Soluble (4.4 g/L) (25°C).

Applications

trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane is used to prepare C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors. It is also used to prepare Mer kinase inhibitors for treatment of pediatric acute lymphoblastic leukemia.

Notes

Store in cool, dry place in tightly closed container. Keep container tightly closed. Store away from oxidizing agent.

Literature References

Liu, J., et al. Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett. 2012, 3(2), 129-134.

Zak, M., et al. Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J. Med. Chem. 2013, 56(11), 764-4785.

Other References

Harmonized Tariff Code
2924.29
TSCA
No

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