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L-Alanine isopropyl ester hydrochloride is a reagent used in the synthesis of anti- hepatitis C virus prodrugs based on imidazotriazine and pyrrolotriazine molecules. Further, it reacts with (1R:2R)-2-Hydroxy-πnanone-3 to prepare isopropyl (1R,2R,5R)-2'-[(2-hydroxypinan-3-ylene)amino]propanoate.
Zhao, C.; Wang, Y.; Ma, S. Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors. Eur. J. Med. Chem. 2015, 102, 188-214.
Ross, B. S.; Ganapati Reddy, P.; Zhang, H. R.; Rachakonda, S.; Sofia, M. J. Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates. J. Org. Chem. 2011, 76 (20), 8311-8319.