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112108-73-3 - 2-Chloro-4-fluoro-5-nitrotoluene, 97% - 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene - H63244 - Alfa Aesar

H63244 2-Chloro-4-fluoro-5-nitrotoluene, 97%

CAS Number
112108-73-3
Synonyms
1-Chloro-5-fluoro-2-methyl-4-nitrobenzene

Size Price ($) Quantity Availability
1g 17.60
5g 76.46
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2-Chloro-4-fluoro-5-nitrotoluene, 97%

MDL
MFCD11110549

Chemical Properties

Formula
C7H5ClFNO2
Formula Weight
189.57
Solubility
Slightly soluble in water.

Applications

2-Chloro-4-fluoro-5-nitrotoluene, is used as a pharmaceutical intermediate. It is also used as Ceritinib intermediate.

Notes

Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents.

Literature References

TH Marsilje.; W Pei.; B Chen.; W Lu.; T Uno. Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials. J. Med. Chem..201356 (14), 5675-5690.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P363-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2904.90
TSCA
No

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