Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

H63244 2-Chloro-4-fluoro-5-nitrotoluene, 97%

CAS Number
112108-73-3
Synonyms
1-Chloro-5-fluoro-2-methyl-4-nitrobenzene

Stock No. Size Price ($) Quantity Availability
H63244-03 1g 23.70
H63244-06 5g 93.20
Add to Cart Add to Quote Request View Item

2-Chloro-4-fluoro-5-nitrotoluene, 97%

MDL
MFCD11110549

Chemical Properties

Formula
C7H5ClFNO2
Formula Weight
189.57
Storage & Sensitivity
Ambient temperatures.
Solubility
Slightly soluble in water.

Applications

2-Chloro-4-fluoro-5-nitrotoluene, is used as a pharmaceutical intermediate. It is also used as Ceritinib intermediate.

Notes

Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents.

Literature References

TH Marsilje.; W Pei.; B Chen.; W Lu.; T Uno. Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials. J. Med. Chem..201356 (14), 5675-5690.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H332-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2904.99
TSCA
No

Recommended

  • 38706

    Thymolphthalein, 0.05% w/v solution in ethanol
  • 10111

    Bismuth powder, -325 mesh, 99.5% (metals basis)
  • B23656

    4-Chloro-3-(trifluoromethyl)benzoic acid, 97+%
  • A19930

    Sodium 3-bromopropanesulfonate, 97%
  • H32730

    4-Methoxy-2-(trifluoromethyl)benzylamine, 97%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware