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It is used in the preparation of highly selective thrombin inhibitors. Also used in the preparation of thiopeptides and thioacylating agents.
Kurt Hilpert; Jean Ackermann; David W. Banner; Alain Gast; Klaus Gubernator; Paul Hadvary; Ludvik Labler; Klaus Mueller; Gerard Schmid,. Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors. J. Med. Chem. 1994, 37(23), 3889-3901.
M. Ashraf Shalaby; Christopher W. Grote; and Henry Rapoport. Thiopeptide Synthesis. α-Amino Thionoacid Derivatives of Nitrobenzotriazole as Thioacylating Agents. J. Org. Chem. 1996, 61(25), 9045-9048.