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H63583 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in dichloromethane

CAS Number
68957-94-8
Synonyms
1-Propanephosphonic acid cyclic anhydride
T3P

Stock No. Size Price ($) Quantity Availability
H63583-09 10g 27.60
H63583-18 50g 68.90
H63583-30 250g 229.00
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1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in dichloromethane

MDL
MFCD00006583
EINECS
422-210-5

Chemical Properties

Formula
C9H21O6P3
Formula Weight
318.19
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.

Applications

1-Propylphosphonic acid cyclic anhydride is used as a reagent for amide/peptide bond formation. It is utilized for condensation reactions and alcohol oxidations. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Notes

Moisture sensitive. Incompatible withstrong oxidizing agents.

Literature References

Madhu, C.; Basavaprabhu,; Vishwanatha, T. M.; Sureshbabu, V. V. T3P (propylphosphonic anhydride) mediated conversion of N α-protected amino/peptide acids into thioacids.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335-H336-H350

Causes severe skin burns and eye damage. May cause respiratory irritation. May cause drowsiness or dizziness. May cause cancer.

Precautionary Statements: P201-P202-P260-P264b-P271-P281-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
5079255
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2931.35
TSCA
Yes

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