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6-Chloro-9-(2-tetrahydropyranyl)purine is used to prepare 6-anilino-9-(2-tetrahydropyranyl)purine by reacting with bromobenzene in the presence of potassium amide as a reagent. Further, it serves as an intermediate in organic synthesis and pharmaceuticals.
Hocek, M.; Holý, A. Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues. Collect. Czech. Chem. Commun. 1999, 64 (2), 229-241.
Taddei, D.; Kilian, P.; Slawin, A. M. Z.; Woollins, J. D. Synthesis and full characterisation of 6-chloro-2-iodopurine, a template for the functionalisation of purines. Org. Biomol. Chem. 2004, 2 (5), 665-670.