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O-tert-Butyl-L-serine tert-butyl ester hydrochloride is a protected L-serine used in peptide synthesis, e.g. synthesis of glycopeptides and lipopeptides and preparation of amino-phospholipids. O-tert-Butyl-L-serine (Ser(TBU-OH), a serine hydroxyl protected amino acid, is used in SPPS such as the synthesis of tailed cyclic RGD peptides to prevent glutarimide formation.
V Cerovský et. al. A convenient incorporation of conformationally constrained 5,5-dimethylproline into the ribonuclease A 89-124 sequence by condensation of synthetic peptide fragments. . Journal of Peptide Research. 2003, 61(3), 140-151 .
Nancy M. Tooney,; Gerald D. Fasman. Synthesis of poly-O-tert-butyl-L-serine and poly-L-serine. Biopolymers. 1968 , 6 (1), 81-96.