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1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous antidepressant and parkinsonism-preventing substance that demonstrates neuroprotectiveactivity. Following systemic administration in rats, 1-Methyl-1,2,3,4-tetrahydroisoquinoline produces antidepressant-like effect similar to the effect of imipramine. 1MeTIQ is a reversible short-acting moderate inhibitor of MAO A/B. Also known as 1,2,3,4-Tetrahydro-1-methylisoquinoline, 1MeTIQ. It is an important raw material and intermediate for revaprazan and pharmaceutical.
Yoshikazu Tasaki; Yukiko Makino; Shigeru Ohta; and Masaaki Hirobe. 1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities. Journal of Neurochemistry. >199157(6), 1940-1943,.
Takahiro Yamakawa; Shigeru Ohta. Isolation of 1-Methyl-1,2,3,4-Tetrahydroisoquinoline-Synthesizing Enzyme from Rat Brain: A Possible Parkinson's Disease-Preventing Enzyme. Biochemical and Biophysical Research Communications. 1997236(3), 676-681,.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant