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H64289 Glycidyl (S)-(+)-3-nitrobenzenesulfonate, 98%

CAS Number
115314-14-2
Synonyms
Glycidyl (S)-(+)-nosylate

Stock No. Size Price ($) Quantity Availability
H64289-03 1g 21.30
H64289-06 5g 66.50
H64289-14 25g 237.00
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Glycidyl (S)-(+)-3-nitrobenzenesulfonate, 98%

MDL
MFCD00064582

Chemical Properties

Formula
C9H9NO6S
Formula Weight
259.23
Melting point
63-66°
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Soluble in chloroform, methylene chloride and tetrahydrofuran. Insoluble in hexane.

Applications

Glycidyl (S)-(+)-3-nitrobenzenesulfonate is used in the synthesis of enantiopure bisoprolol by reacting with phenols using cesium fluoride as catalyst. It is also involved in the preparation of orally active HIV-1 protease inhibitor.

Notes

Moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Literature References

Lee, S.; An, H.; Chang, D. J.; Jang, J.; Kim, K.; Sim, J.; Lee, J.; Suh, Y. G. Total synthesis of (-)-deguelin via an iterative pyran-ring formation strategy. Chem. Commun. 2015, 51 (43), 9026-9029.

Iwahashi, M.; Shimabukuro, A.; Onoda, T.; Matsunaga, Y.; Okada, Y.; Matsumoto, R.; Nambu, F.; Nakai, H.; Toda, M. Discovery of selective indole-based prostaglandin D2 receptor antagonist. Bioorg. Med. Chem. 2011, 19 (15), 4574-4588.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
4704457
Harmonized Tariff Code
2910.90
TSCA
No
RTECS
DB7192010

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