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H64381 4-Hydroxy-6-(trifluoromethyl)pyrimidine, 97%

CAS Number
1546-78-7
Synonyms
6-(Trifluoromethyl)-4-pyrimidinol

Stock No. Size Price ($) Quantity Availability
H64381-03 1g 22.50
H64381-06 5g 106.00
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4-Hydroxy-6-(trifluoromethyl)pyrimidine, 97%

MDL
MFCD00192530

Chemical Properties

Formula
C5H3F3N2O
Formula Weight
164.09
Melting point
169-171°
Storage & Sensitivity
Ambient temperatures.
Solubility
Solubility in methanol (almost transparency). Slightly soluble in water.

Applications

6-(Trifluoromethyl)-4-pyrimidinol is used as building block in chemical synthesis. It may also be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Protect from heat.

Literature References

Qingyong Li, et al. Synthesis and antitumor activity of novel 10-substituted camptothecin analogues.Bioorg Med Chem.,2006,14(21), 7175-7182.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
145548
Harmonized Tariff Code
2933.59
TSCA
No

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