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14774-37-9 - 4-(Hydroxymethyl)tetrahydropyran, 98% - 4-Tetrahydropyranmethanol - H64568 - Alfa Aesar

H64568 4-(Hydroxymethyl)tetrahydropyran, 98%

CAS Number
14774-37-9
Synonyms
4-Tetrahydropyranmethanol

Size Price ($) Quantity Availability
250mg 20.40
1g 52.00
5g 208.00
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4-(Hydroxymethyl)tetrahydropyran, 98%

MDL
MFCD00457804

Chemical Properties

Formula
C6H12O2
Formula Weight
116.16
Boiling Point
111-115°/15mm
Flash Point
61°(142°F)
Refractive Index
1.4600
Solubility
Slightly soluble in water.

Applications

Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

Notes

Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.

Literature References

Paul A. Roethle; Ryan M. McFadden; Hong Yang; Paul Hrvatin; Hon Hui; Michael Graupe; Brian Gallagher; Jessica Chao; Joseph Hesselgesser; Paul Duatschek; Jim Zheng; Bing Lu; Daniel B. Tumas; Jason Perry; and Randall L. Halcomb. Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis. J. Med. Chem.2013 56(18), 7324-7333.

Jennifer M. Frost; Michael J. Dart; Karin R. Tietje; Tiffany R. Garrison; George K. Grayson; Anthony V. Daza; Odile F. El-Kouhen; Betty B. Yao; Gin C. Hsieh; Madhavi Pai; Chang Z. Zhu; Prasant Chandran; and Michael D. Meyer. Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity. J. Med. Chem.2010 53(1), 295-315.

GHS Hazard and Precautionary Statements

Hazard Statements: H318-H315-H335-H227

Causes serious eye damage. Causes skin irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P261-P280-P305+P351+P338-P304+P340-P310-P362-P312-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
103069
Harmonized Tariff Code
2932.99
TSCA
No

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