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H64574 (S)-4-Boc-(3-hydroxymethyl)morpholine, 97%

CAS Number
714971-28-5
Synonyms

Stock No. Size Price ($) Quantity Availability
H64574-MD 250mg 55.20
H64574-03 1g 175.00
H64574-06 5g 803.00
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(S)-4-Boc-(3-hydroxymethyl)morpholine, 97%

MDL
MFCD06799478

Chemical Properties

Formula
C10H19NO4
Formula Weight
217.27
Melting point
80° lit.
Storage & Sensitivity
Store at -20°C.
Solubility
Slightly soluble in water.

Applications

An intermediate of BMS-599626, a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

Notes

Store in freezer at (-20°C). Keep container tightly closed. Store away from oxidizing agent.

Literature References

Weiya Xia; Yiu-Keung Lau; Hua-Zhong Zhang; Fen-Yuan Xiao; Dennis A. Johnston; Ai-Ru Liu; Lei Li; Ruth L. Katz; and Mien-Chie Hung. Combination of EGFR, HER-2/neu, and HER-3 Is a Stronger Predictor for the Outcome of Oral Squamous Cell Carcinoma Than Any Individual Family Members1. Clin Cancer Res. 1999 54164.

John T. Hunt; Toomas Mitt; Robert Borzilleri; Johnni Gullo-Brown; Joseph Fargnoli; Brian Fink; Wen-Ching Han; Steven Mortillo; Gregory Vite; Barri Wautlet; Tai Wong; Chiang Yu; Xiaoping Zheng; and Rajeev Bhide. Discovery of the Pyrrolo[2,1-f][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template. Clin Cancer Res. 2004 47(16), 4054-4059.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
10251196
Harmonized Tariff Code
2934.99
TSCA
No

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