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An intermediate of BMS-599626, a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.
Weiya Xia; Yiu-Keung Lau; Hua-Zhong Zhang; Fen-Yuan Xiao; Dennis A. Johnston; Ai-Ru Liu; Lei Li; Ruth L. Katz; and Mien-Chie Hung. Combination of EGFR, HER-2/neu, and HER-3 Is a Stronger Predictor for the Outcome of Oral Squamous Cell Carcinoma Than Any Individual Family Members1. Clin Cancer Res. 1999 54164.
John T. Hunt; Toomas Mitt; Robert Borzilleri; Johnni Gullo-Brown; Joseph Fargnoli; Brian Fink; Wen-Ching Han; Steven Mortillo; Gregory Vite; Barri Wautlet; Tai Wong; Chiang Yu; Xiaoping Zheng; and Rajeev Bhide. Discovery of the Pyrrolo[2,1-f][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template. Clin Cancer Res. 2004 47(16), 4054-4059.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant