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714971-28-5 - (S)-4-Boc-(3-hydroxymethyl)morpholine, 97% - H64574 - Alfa Aesar

H64574 (S)-4-Boc-(3-hydroxymethyl)morpholine, 97%

CAS Number
714971-28-5
Synonyms

Size Price ($) Quantity Availability
250mg 58.80
1g 188.00
5g 784.00
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(S)-4-Boc-(3-hydroxymethyl)morpholine, 97%

MDL
MFCD06799478

Chemical Properties

Formula
C10H19NO4
Formula Weight
217.27
Melting point
80° lit.
Solubility
Slightly soluble in water.

Applications

An intermediate of BMS-599626, a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

Notes

Store in freezer at (-20°C). Keep container tightly closed. Store away from oxidizing agent.

Literature References

Weiya Xia; Yiu-Keung Lau; Hua-Zhong Zhang; Fen-Yuan Xiao; Dennis A. Johnston; Ai-Ru Liu; Lei Li; Ruth L. Katz; and Mien-Chie Hung. Combination of EGFR, HER-2/neu, and HER-3 Is a Stronger Predictor for the Outcome of Oral Squamous Cell Carcinoma Than Any Individual Family Members1. Clin Cancer Res. 1999 54164.

John T. Hunt; Toomas Mitt; Robert Borzilleri; Johnni Gullo-Brown; Joseph Fargnoli; Brian Fink; Wen-Ching Han; Steven Mortillo; Gregory Vite; Barri Wautlet; Tai Wong; Chiang Yu; Xiaoping Zheng; and Rajeev Bhide. Discovery of the Pyrrolo[2,1-f][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template. Clin Cancer Res. 2004 47(16), 4054-4059.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
10251196
Harmonized Tariff Code
2934.99
TSCA
No

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