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A pyridine derivative used in the preparation of inhibitors of Acyl CoA, cholesterol acyltransferase as well as bone morphogenetic protein (BMP) signaling inhibitors.
Gregory D. Cuny, Paul B. Yu; Joydev K. Lahaa; Xuechao Xinga; Ji-Feng Liu; Carol S. Lai; Donna Y. Deng; Chetana Sachidanan; and Kenneth D. Blochb; Randall T. Petersond. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008 18(15), 4388-4392.
Wayne Vaccaro; Cindy Amore; Joel Berger; Robert Burrier; John Clader; Harry Davis; Martin Domalski; Tom Fevig; Brian Salisbury , and Rosy Sher. Inhibitors of Acyl CoA:Cholesterol Acyltransferase. J. Med. Chem. 1996 39(8), 1704-1719.
Hazard Statements: H302+H312+H332-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant