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2-Bromo-6-chlorobenzaldehyde plays an important role as a linker, which provides higher selectivity and reactivity in the Buchwald C-N bond forming reaction in order to prepare Bruton's tyrosine kinase inhibitor.
Sahn, J. J.; Su, J. Y.; Martin, S. F. Facile and unified approach to skeletally diverse, privileged scaffolds. 2011, 13 (10), 2590-2593.
Donald, J. R.; Granger, B. A.; Hardy, S.; Sahn, J. J.; Martin, S. F. Applications of Multicomponent Assembly Processes To the Facial Synthesis of Diversely Functionalized Nitrogen Heterocycles. 2012, 84 (2), 1089.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.