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It is used as pharmaceutical intermediate. A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme.
John W. Ellingboe.; Walter Spinelli.; Michael W. Winkley.; Thomas T. Nguyen.; Roderick W. Parsons.; Issam F. Moubarak.; Jan M. Kitzen.; Donna Von Engen.; Jehan F. Bagli. Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides.J. Med. Chem. 1992, 35 (4), .
Abraham Ulman.; Craig S. Willand.; Werner Kohle.; Douglas R. Robello.; David J. Williams.; Laura Handley. New sulfonyl-containing materials for nonlinear optics: semiempirical calculations, synthesis, and properties.J. Am. Chem. Soc. 1990, 112 (20),7083-7090 .
Hazard Statements: H302-H312-H332-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.