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53220-41-0 - 4-(4-Chlorobenzoyl)piperidine, 97% - H64740 - Alfa Aesar

H64740 4-(4-Chlorobenzoyl)piperidine, 97%

CAS Number
53220-41-0
Synonyms

Size Price ($) Quantity Availability
250mg 26.10
1g 78.30
5g 211.41
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4-(4-Chlorobenzoyl)piperidine, 97%

MDL
MFCD04113538

Chemical Properties

Formula
C12H14ClNO
Formula Weight
223.70
Melting point
60-63°
Solubility
Slightly soluble in water.

Applications

It is used as pharmaceutical intermediate. The derivative of this compound, 2-amino-3-(4-chlorobenzoyl)-4-[4-(alkyl/aryl)piperazin-yl]thiophene are used as allosteric enhancers of the A1-adenosine receptor.

Notes

Store in cool dry place. Keep container tightly closed. Incompatible with oxidizing agents.

Literature References

Rodney W. Stevens.; Kazunari Nakao.; Hiroki Koike.; Yoshinori Murata Stéphane Caron.; Enrique Vazquez. Efficient Synthesis of [6-Chloro-2-(4-chlorobenzoyl)-1H-indol-3-yl]-acetic Acid, a Novel COX-2 Inhibitor.J. Org. Chem. 2003, 68 (10),4104-4107 .

Romeo Romagnoli.; Pier Giovanni Baraldi.; Maria Dora Carrion.; Carlota Lopez Cara.; Olga Cruz-Lopez.; Maria Antonietta Iaconinoto.; Delia Preti.; John C. Shryock.; Allan R. Moorman.; Fabrizio Vincenzi.; Katia Varani.; Pier Andrea Bore. Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1 Adenosine Receptor.J. Med. Chem. 2008, 51 (18),5875-5879 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
158791
Harmonized Tariff Code
2933.39
TSCA
No

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