Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

1535-65-5 - Difluoromethyl phenyl sulfone, 95% - (Difluoromethylsulfonyl)benzene - H64760 - Alfa Aesar

H64760 Difluoromethyl phenyl sulfone, 95%

CAS Number
1535-65-5
Synonyms
(Difluoromethylsulfonyl)benzene

Size Price ($) Quantity Availability
250mg 21.40
1g 64.30
5g 257.00
Add to Cart Add to Quote Request View Item

Difluoromethyl phenyl sulfone, 95%

MDL
MFCD01050170

Chemical Properties

Formula
C7H6F2O2S
Formula Weight
192.18
Melting point
24-25°
Density
1.324
Refractive Index
1.5000
Solubility
Soluble in chloroform and water.

Applications

Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.

Notes

Keep container tightly closed. With adequate ventilation. Store away from oxidizing agent.

Literature References

G K Surya Prakash; Jinbo Hu; George A Olah. Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. Journal of Organic Chemistry.2003 68(11), 4457-4463.

Chuanfa Ni; Laijun Zhang; Jinbo Hu. Nucleophilic fluoroalkylation of alpha,beta-enones, arynes, and activated alkynes with fluorinated sulfones: probing the hard/soft nature of fluorinated carbanions. Journal of Organic Chemistry.2008 73(15), 5699-5713.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2259218
Harmonized Tariff Code
2930.90
TSCA
No

Recommended

  • A15111

    Mesityl oxide, 90+%, remainder 4-methyl-4-penten-2-one
  • A16010

    cis-Aconitic acid, tech. 90%
  • A19890

    Sodium sulfate, anhydrous, 99%
  • B22918

    N,N-Diisopropylbenzamide, 99%
  • B23726

    (3-Mercaptopropyl)trimethoxysilane, 95%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware