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68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile - 1-Propanephosphonic acid cyclic anhydride - T3P - H66967 - Alfa Aesar

H66967 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile

CAS Number
68957-94-8
Synonyms
1-Propanephosphonic acid cyclic anhydride
T3P

Size Price ($) Quantity Availability
50g 34.10
250g 137.00
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1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile

MDL
MFCD00006583
EINECS
422-210-5

Chemical Properties

Formula
C9H21O6P3
Formula Weight
318.19
Solubility
Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.

Applications

1-Propylphosphonic acid cyclic anhydride is used as a reagent for amide/peptide bond formation. It is utilized for condensation reactions and alcohol oxidations. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Notes

Moisture sensitive. Incompatible with strong oxidizing agents.

Literature References

Madhu, C.; Basavaprabhu.; Vishwanatha, T. M.; Sureshbabu, V. V. T3P (propylphosphonic anhydride) mediated conversion of Nα-protected amino/peptide acids into thioacids. 2012, 53 (11), 1406-1409.

Nagendra, G.; Madhu, C.; Vishwanatha, T. M.; Sureshbabu, V. V. An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator. Tetrahedron Lett. 2012, 53 (38), 5059-5063.

Prasanna, T. S. R.; Raju, K. M. Quick Access to Bis(indolyl)methanes: T3P as a Novel Catalyst System. J. Korean Chem. Soc. 2012, 56 (1), 1406-1409.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H303-H312-H333-H314-H318

Highly flammable liquid and vapour. May be harmful if swallowed. Harmful in contact with skin. May be harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
5079255
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2934.99
TSCA
No

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