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68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile - 1-Propanephosphonic acid cyclic anhydride - T3P - H66967 - Alfa Aesar

H66967 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile

CAS Number
1-Propanephosphonic acid cyclic anhydride

Size Price ($) Quantity Availability
50g 34.10
250g 137.00
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1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile


Chemical Properties

Formula Weight
Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.


1-Propylphosphonic acid cyclic anhydride is used as a reagent for amide/peptide bond formation. It is utilized for condensation reactions and alcohol oxidations. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.


Moisture sensitive. Incompatible with strong oxidizing agents.

Literature References

Madhu, C.; Basavaprabhu.; Vishwanatha, T. M.; Sureshbabu, V. V. T3P (propylphosphonic anhydride) mediated conversion of Nα-protected amino/peptide acids into thioacids. 2012, 53 (11), 1406-1409.

Nagendra, G.; Madhu, C.; Vishwanatha, T. M.; Sureshbabu, V. V. An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator. Tetrahedron Lett. 2012, 53 (38), 5059-5063.

Prasanna, T. S. R.; Raju, K. M. Quick Access to Bis(indolyl)methanes: T3P as a Novel Catalyst System. J. Korean Chem. Soc. 2012, 56 (1), 1406-1409.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H314-H312-H303-H333

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Harmful in contact with skin. May be harmful if swallowed. May be harmful if inhaled.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


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