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J14710 Diethyl pyrocarbonate, 97+%, Ultrapure, Thermo Scientific

CAS Number
1609-47-8
Synonyms
DEPC
Diethyl dicarbonate

Stock No. Size Price ($) Quantity Availability
J14710-AC 25ml 122.00
J14710-AE 100ml 365.00
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Diethyl pyrocarbonate, 97+%, Ultrapure, Thermo Scientific

MDL
MFCD00009106
EINECS
216-542-8

Chemical Properties

Formula
C6H10O5
Formula Weight
162.14
Form
Liquid
Melting point
69°
Boiling Point
93-94°/18mm
Flash Point
69°(156°F)
Density
1.101
Refractive Index
1.398
Storage & Sensitivity
Store at -20°C.

Applications

  • A strong, nonspecific inhibitor of ribonuclease
  • Reacts with the N1 of histidine residues in proteins under mild conditions
  • Used to cross-link and modify proteins by ethoxyformylation of NH2 and imidazole groups in proteins
  • Reacts with amines and thus cannot be used with Tris Buffer

Literature References

Tsurushiin, S., Hiramatsu, A., Inamasu, M. and Yasunobu, K. T. Biochim. Biophys. Acta. 1975, 400, 451-460.

Meyer, S. E. and Cromartie, T. H. Biochemistry 1980, 19, 1874-1881.

Berger, S. L. Anal. Biochem. 1975, 67, 428-437.

Leonard, N. J., Mcdonald, J. J., Henderson, R. E. and Reichmann, M. E. Biochemistry 1971, 10, 3335-3342.

Roberts, M. F., Deems, R. A., Mincey, T. C. and Dennis, E. A. J. Biol. Chem. 1977, 252, 2405-2411

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H302-H315-H319-H332-H335

Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P235-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,7998
Beilstein
637031
Harmonized Tariff Code
2920.90
TSCA
Yes
RTECS
LQ9350000

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