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357-08-4 - Naloxone hydrochloride, 98% - J60013 - Alfa Aesar

J60013 Naloxone hydrochloride, 98%

CAS Number
357-08-4
Synonyms

Size Price ($) Quantity Availability
100mg 64.90
500mg 154.44
1g 386.83
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Naloxone hydrochloride, 98%

MDL
MFCD00069322
EINECS
206-611-0

Chemical Properties

Formula
C19H21NO4•HCl
Formula Weight
363.84
Form
Crystalline powder
Melting point
200-205°
Solubility
Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml) and dimethyl sulfoxide (73 mg/ml). Insoluble in ether

Applications

A specific opiate antagonist. Blocks the action of sigma-agonists at opioid sites. It is used as an antidote for opioid overdose or for the prevention of overdose. Also used in combination with buprenorphine in the treatment of opiate addiction and in pain management.

Notes

Refrigerate. Keep container tightly closed. Store away from oxidizing agent.

Literature References

Le Bourdonnec, B., Barker, W.M., Belanger, S. et al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as ? opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett.20086(18), 2006-2012.

Boyer, E.W. Management of opioid analgesic overdose. N Engl J Med.2012367(2), 146-155.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6362
Harmonized Tariff Code
2939.19
TSCA
No
RTECS
QD2275000

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