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TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel. Clotrimazole impurity. Also used to study its effect on the prevention of vascular restenosis after balloon angioplasty.
H Wulff; M J Miller; W Hansel; S Grissmer; M D Cahalan; K G Chandy. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. PNAS, 97(14), 8151-8156.
K George Chandy; Heike Wulff; Christine Beeton; Michael Pennington; George A Gutman; Michael D Cahalan. K+ channels as targets for specific immunomodulation. Trends in Pharmacological Sciences, 2004, 25(5), 280-289.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.