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289905-88-0 - TRAM 34 - 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole - J60019 - Alfa Aesar

J60019 TRAM 34

CAS Number
289905-88-0
Synonyms
1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Size Price ($) Quantity Availability
25mg 243.00
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TRAM 34

MDL
MFCD09842562

Chemical Properties

Formula
C22H17ClN2
Formula Weight
344.84
Form
Powder
Melting point
145-147°
Solubility
Soluble in DMSO at 2mg/ml. Insoluble in water

Applications

TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel. Clotrimazole impurity. Also used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Notes

Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

H Wulff; M J Miller; W Hansel; S Grissmer; M D Cahalan; K G Chandy. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. PNAS, 97(14), 8151-8156.

K George Chandy; Heike Wulff; Christine Beeton; Michael Pennington; George A Gutman; Michael D Cahalan. K+ channels as targets for specific immunomodulation. Trends in Pharmacological Sciences, 2004, 25(5), 280-289.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.19
TSCA
No

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