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1684-40-8 - Tacrine hydrochloride - 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride - THA hydrochloride - J60070 - Alfa Aesar

J60070 Tacrine hydrochloride

CAS Number
1684-40-8
Synonyms
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride
THA hydrochloride

Size Price ($) Quantity Availability
500mg 0.00
5g 167.00
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Tacrine hydrochloride

MDL
MFCD00150067
EINECS
216-867-5

Chemical Properties

Formula
C13H14N2•HCl
Formula Weight
234.73(anhy)
Form
Crystalline solid
Melting point
283-284°
Solubility
Soluble in aqueous buffers

Applications

A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.

Notes

Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Shuai Qian; Lisi He; Marvin Mak; Yifan Han; Chun-Yu Ho; Zhong Zuo. Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. International Journal of Pharmaceutics, 2014, 477(1-2), 442-453.

Jinggong Liu et. al. Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - General Subjects, 2006,1840(9).

GHS Hazard and Precautionary Statements

Hazard Statements: H331-H302-H315-H319-H335

Toxic if inhaled. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P311-P362-P301+P312-P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9024
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
AR9532500

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