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J60131 2-Iminothiolane hydrochloride

CAS Number
4781-83-3
Synonyms
2-Thiolanimine hydrochloride
Traut's reagent

Stock No. Size Price ($) Quantity Availability
J60131-MD 250mg 153.00
J60131-03 1g 203.00
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2-Iminothiolane hydrochloride

MDL
MFCD00039013

Chemical Properties

Formula
C4H7NS•HCl
Formula Weight
137.63
Form
Powder
Melting point
190-195°
Storage & Sensitivity
Keep Cold.
Solubility
Freely soluble in water

Applications

2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..

Notes

Protect from moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away fom strong oxidizing agents.

Literature References

A Bernkop-Schnürch.; M Hornof.; T Zoidl. Thiolated polymers—thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. International Journal of Pharmaceutics. 2003, 260,(2), 229-237.

R Jue.; JM Lambert.; LR Pierce.; RR Traut. Addition of sulfhydryl groups of Escherichia coli ribosomes by protein modification with 2-iminothiolane (methyl 4-mercaptobutyrimidate). Biochemistry. 1978, 17,(25), 5399-5406.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3620079
Harmonized Tariff Code
2934.99
TSCA
No

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