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J60139 Everolimus

CAS Number
159351-69-6
Synonyms

Stock No. Size Price ($) Quantity Availability
J60139-#0 5mg 144.00
J60139-MA 10mg 213.00
J60139-MB 25mg 367.00
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Everolimus

MDL
MFCD07785165

Chemical Properties

Formula
C53H83NO14
Formula Weight
958.22
Form
Powder
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.

Applications

Everolimus is a rapamycin analog. It is used to treat certain types of kidney cancer, breast cancer and brain tumor. It prevents transplant rejection by decreasing the activity of the immune system. It also act as a kinase inhibitor. It is used in the treatment of subependymal giant cell astrocytoma (SEGA; a type of brain tumor) in adults and children 1 year of age and older who have TSC.

Notes

Incompatible with strong oxidizing agents.

Literature References

Puricel, S.; Arroyo, D.; Corpataux N.; Baeriswyl, G.; Lehmann, N.; Kallinikou, Z.; Muller, O.; Allard, L.; Stauffer, J.; Togni, M.; Goy, J.; Cook, S. Comparison of Everolimus- and Biolimus-Eluting Coronary Stents With Everolimus-Eluting Bioresorbable Vascular Scaffolds. J. Am. Coll. Cardiol. 2015, 65 (8), 791-801.

Naruse, T.; Yanamoto, S.; Yamada, S.; Rokutanda, S.; Kawakita, A.; Kawasaki, G.; Umeda, M. Anti-Tumor Effect of the Mammalian Target of Rapamycin Inhibitor Everolimus in Oral Squamous Cell Carcinoma. Pathol. Oncol. Res. 2015, 21 (3), 765-773.

GHS Hazard and Precautionary Statements

Hazard Statements: H372

Causes damage to organs through prolonged or repeated exposure.

Precautionary Statements: P260-P264b-P270-P314-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Get medical advice/attention if you feel unwell. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3907
Harmonized Tariff Code
2934.99
TSCA
No

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