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Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells.
GJ D'Angio.; S Farber.; CL Maddock. Potentiation of X-Ray Effects by Actinomycin D 1. Radiology. 1959, 73,(2), 16-21.
RP Perry.; DE Kelley. Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. Journal of Cellular Physiology. 1959, 76,(2), 127-139.
Hazard Statements: H300-H336-H373
Fatal if swallowed. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P264b-P270-P271-P301+P310-P304+P340-P312-P314-P330-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant