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J60148 Actinomycin D

CAS Number
50-76-0
Synonyms
Dactinomycin
Actinomycin C1

Stock No. Size Price ($) Quantity Availability
J60148-#0 5mg 89.80
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Actinomycin D

MDL
MFCD00005033
EINECS
200-063-6

Chemical Properties

Formula
C62H86N12O16
Formula Weight
1255.40
Form
Powder
Melting point
251-253°
Storage & Sensitivity
Store at -20°C.
Solubility
It is soluble ino 50 mM in DMSO.

Applications

Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

GJ D'Angio.; S Farber.; CL Maddock. Potentiation of X-Ray Effects by Actinomycin D 1. Radiology. 1959, 73,(2), 16-21.

RP Perry.; DE Kelley. Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. Journal of Cellular Physiology. 1959, 76,(2), 127-139.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H336-H373

Fatal if swallowed. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements: P260-P264b-P270-P271-P301+P310-P304+P340-P312-P314-P330-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2800
Beilstein
605235
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
AU1575000

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