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50-76-0 - Actinomycin D - Dactinomycin - Actinomycin C1 - J60148 - Alfa Aesar

J60148 Actinomycin D

CAS Number
50-76-0
Synonyms
Dactinomycin
Actinomycin C1

Size Price ($) Quantity Availability
5mg 78.80
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Actinomycin D

MDL
MFCD00005033
EINECS
200-063-6

Chemical Properties

Formula
C62H86N12O16
Formula Weight
1255.40
Form
Powder
Melting point
251-253°
Solubility
It is soluble ino 50 mM in DMSO.

Applications

Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

GJ D'Angio.; S Farber.; CL Maddock. Potentiation of X-Ray Effects by Actinomycin D 1. Radiology. 1959, 73,(2), 16-21.

RP Perry.; DE Kelley. Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species. Journal of Cellular Physiology. 1959, 76,(2), 127-139.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H360

Fatal if swallowed. May damage fertility or the unborn child.

Precautionary Statements: P201-P280-P301+P310a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2800
Beilstein
605235
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
AU1575000

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