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J60155 Okadaic acid, 98%

CAS Number
78111-17-8
Synonyms

Stock No. Size Price ($) Quantity Availability
J60155-I& 50microgram 98.90
J60155-!G 100microg 175.00
J60155-!S 300microg 474.00
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Okadaic acid, 98%

MDL
MFCD00083455

Chemical Properties

Formula
C44H68O13
Formula Weight
805.02
Form
Powder
Storage & Sensitivity
Store at -20°C.
Solubility
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Applications

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Literature References

Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature .  1989, 337,(6202), 78-81.

Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H315-H319-H331

Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. Toxic if inhaled.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P311-P330-P332+P313-P337+P313-P361-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,6819
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2932.19
TSCA
No
RTECS
AA8227800

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