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78111-17-8 - Okadaic acid, 98% - J60155 - Alfa Aesar

J60155 Okadaic acid, 98%

CAS Number
78111-17-8
Synonyms

Size Price ($) Quantity Availability
50microgram 94.10
100microg 167.00
300microg 451.00
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Okadaic acid, 98%

MDL
MFCD00083455

Chemical Properties

Formula
C44H68O13
Formula Weight
805.02
Form
Powder
Solubility
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Applications

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Literature References

Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature .  1989, 337,(6202), 78-81.

Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330-H315

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation.

Precautionary Statements: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6819
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2932.19
TSCA
No
RTECS
AA8227800

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