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Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.
Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature . 1989, 337,(6202), 78-81.
Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.
Hazard Statements: H300-H310-H330-H315
Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation.
Precautionary Statements: P301+P310a-P304+P340-P320-P330-P405-P501a
IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.