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65-19-0 - Yohimbine hydrochloride, 98+% - 17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride - J60185 - Alfa Aesar

J60185 Yohimbine hydrochloride, 98+%

CAS Number
65-19-0
Synonyms
17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride

Size Price ($) Quantity Availability
1g 40.77
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Yohimbine hydrochloride, 98+%

MDL
MFCD00012674
EINECS
200-600-4

Chemical Properties

Formula
C21H26N2O3•HCl
Formula Weight
390.91
Form
Powder
Melting point
288-290°
Sensitivity
Light Sensitive
Solubility
Soluble in dimethyl sulfoxide and methanol.

Applications

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure.

Notes

Light Sensitive, store in dark. Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

W Zhang and G M Roomans. A yohimbine-dependent, UK14,304 induced ion transient in HT29 cells studied by X-ray microanalysis. Scanning microscopy, 1996, 10(1), 293-299.

Susan X. Jiang et. al. Reversible inhibition of intracellular calcium influx through NMDA receptors by imidazoline I2receptor antagonists. European Journal of Pharmacology, 2010,629,(1), 12-19.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.

Precautionary Statements: P260-P284-P301+P310-P304+P340-P320-P330-P361-P302+P350-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,10102
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2939.99
TSCA
Yes
RTECS
ZG1015000

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