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Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure.
W Zhang and G M Roomans. A yohimbine-dependent, UK14,304 induced ion transient in HT29 cells studied by X-ray microanalysis. Scanning microscopy, 1996, 10(1), 293-299.
Susan X. Jiang et. al. Reversible inhibition of intracellular calcium influx through NMDA receptors by imidazoline I2receptor antagonists. European Journal of Pharmacology, 2010,629,(1), 12-19.
Hazard Statements: H300-H311-H331-H373
Fatal if swallowed. Toxic in contact with skin. Toxic if inhaled. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P312-P314-P330-P361-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant