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26305-03-3 - Pepstatin A, 98% - J60237 - Alfa Aesar

J60237 Pepstatin A, 98%

CAS Number
26305-03-3
Synonyms

Size Price ($) Quantity Availability
5mg 38.83
25mg 128.75
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Pepstatin A, 98%

MDL
MFCD00060740
EINECS
247-600-0

Chemical Properties

Formula
C34H63N5O9
Formula Weight
685.90
Form
Powder
Melting point
233° dec.
Solubility
It is soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60°C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.

Applications

Pepstatin A, is used as an irreversible inhibitor of HIV-1, aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away fom strong acids, strong bases.

Literature References

S Fukuta.; M Oyama.; K Kavalkovich.; FH Fu.; C Niyibizi. Identification of types II, IX and X collagens at the insertion site of the bovine achilles tendon. J.Biol.Chem.  1976, 25;251(22), 7088-94.

Sato et al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 2007, 67(20), 9677-84.

Other References

Merck
14,7147
Beilstein
2201362
Harmonized Tariff Code
2924.19
TSCA
No
RTECS
SC6155000

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