Pepstatin A, is used as an irreversible inhibitor of HIV-1, aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.
S Fukuta.; M Oyama.; K Kavalkovich.; FH Fu.; C Niyibizi. Identification of types II, IX and X collagens at the insertion site of the bovine achilles tendon. J.Biol.Chem. 1976, 25;251(22), 7088-94.
Sato et al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 2007, 67(20), 9677-84.