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118409-57-7 - Tyrphostin A23, 99% - Tyrphostin AG-18 - 2-(3,4-Dihydroxybenzylidene)malononitrile - J60308 - Alfa Aesar

J60308 Tyrphostin A23, 99%

CAS Number
118409-57-7
Synonyms
Tyrphostin AG-18
2-(3,4-Dihydroxybenzylidene)malononitrile

Size Price ($) Quantity Availability
5mg 60.66
10mg 131.84
25mg 243.20
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Tyrphostin A23, 99%

MDL
MFCD00133899

Chemical Properties

Formula
C10H6N2O2
Formula Weight
186.17
Form
Powder
Solubility
Soluble in DMSO, ethanol, or DMF

Applications

Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.

Literature References

S Dunzendorfer; P Schratzberger; N Reinisch, C M Kähler; C J Wiedermann. Secretoneurin, a novel neuropeptide, is a potent chemoattractant for human eosinophils. Blood.1998, 91 (5), 1527-1532.

A Gazit; P Yaish; C Gilon; A Levitzki. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of Medicinal Chemistry. 1989, 32, (10), 2344-2352.

Other References

Harmonized Tariff Code
2926.90
TSCA
No

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