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Astemizole, is used as a potent and selective H1-receptor antagonist that displays antihistamine and antimalarial activity. It is also been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.
Cavalli et al. Towards a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of hERG K+ channel blockers. . J.Med.Chem.. 2002, 45,(18), 3844-53.
Chong et al. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat.Chem.Biol. 2006, 2,(8), 415-6.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant