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J60342 Clofibrate, 95+%

CAS Number
637-07-0
Synonyms
Ethyl 2-(4-chlorophenoxy)isobutyrate
2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester

Stock No. Size Price ($) Quantity Availability
J60342-03 1g 19.00
J60342-06 5g 21.80
J60342-14 25g 85.10
J60342-22 100g 244.00
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Clofibrate, 95+%

MDL
MFCD00000615
EINECS
211-277-4

Chemical Properties

Formula
C12H15ClO3
Formula Weight
242.70
Form
Liquid
Boiling Point
154-156°
Flash Point
113°(235°F)
Density
1.14
Refractive Index
1.5
Storage & Sensitivity
Keep Cold.
Solubility
Soluble to 100 mM in DMSO.

Applications

It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450’s CYP4A1 and CYP4A3.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, bases. Store in refrigerator.

Literature References

S Oikawa; H Midorikawa.[Clofibrate treatment of hyperlipoproteinemia]. Nippon rinsho. Japanese journal of clinical medicine.1994, 52 (12), 3285-3291.

W Reuter; A Seifert. [The treatment of essential hyperlipidemia with clofibrate]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1969, 24 (1), Suppl-Supp7.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Precautionary Statements: P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2377
Beilstein
1913459
Hazard Class
9
Packing Group
III
Harmonized Tariff Code
2918.99
TSCA
No
RTECS
UE9480000

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