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637-07-0 - Clofibrate, 95+% - Ethyl 2-(4-chlorophenoxy)isobutyrate - 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester - J60342 - Alfa Aesar

J60342 Clofibrate, 95+%

CAS Number
637-07-0
Synonyms
Ethyl 2-(4-chlorophenoxy)isobutyrate
2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester

Size Price ($) Quantity Availability
1g 5.20
5g 20.29
25g 78.20
100g 241.02
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Clofibrate, 95+%

MDL
MFCD00000615
EINECS
211-277-4

Chemical Properties

Formula
C12H15ClO3
Formula Weight
242.70
Form
Liquid
Boiling Point
154-156°
Flash Point
113°(235°F)
Density
1.14
Refractive Index
1.5
Solubility
Soluble to 100 mM in DMSO.

Applications

It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450’s CYP4A1 and CYP4A3.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, bases. Store in refrigerator.

Literature References

S Oikawa; H Midorikawa.[Clofibrate treatment of hyperlipoproteinemia]. Nippon rinsho. Japanese journal of clinical medicine.1994, 52 (12), 3285-3291.

W Reuter; A Seifert. [The treatment of essential hyperlipidemia with clofibrate]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1969, 24 (1), Suppl-Supp7.

GHS Hazard and Precautionary Statements

Hazard Statements: H318-H315-H302-H335-H411-H401

Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause respiratory irritation. Toxic to aquatic life with long lasting effects. Toxic to aquatic life.

Precautionary Statements: P261-P273-P280-P305+P351+P338-P304+P340-P310-P362-P301+P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2377
Beilstein
1913459
Hazard Class
9
Packing Group
III
Harmonized Tariff Code
2918.99
TSCA
No
RTECS
UE9480000

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