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474-25-9 - Chenodeoxycholic acid - J60364 - Alfa Aesar

J60364 Chenodeoxycholic acid

CAS Number
474-25-9
Synonyms

Size Price ($) Quantity Availability
5g 65.10
25g 198.00
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Chenodeoxycholic acid

MDL
MFCD00064142
EINECS
207-481-8

Chemical Properties

Formula
C24H40O4
Formula Weight
392.57
Form
Needle crystals
Melting point
164-168°
Solubility
Soluble in water, dimethyl sulfoxide, ethanol and dimethylformamide.

Applications

Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.

Notes

Incompatible with strong oxidizing agents.

Literature References

Zhang, Y.; Qu, H.; Feng, H.; Wang, X.; Shan, W.; Zeng, W.; Wang, Q.; Zhao, Y. Development of an enzyme-linked immunosorbent assay for chenodeoxycholic acid using an anti-chenodeoxycholic acid monoclonal antibody. Anal. Methods 2015, 7 (11), 4583-4589.

Jones, R. D.; Lopez, A. M.; Tong, E. Y.; Posey, K. S.; Chuang, J. C.; Repa, J. J.; Turley, S. D. Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice. Steroids 2015, 93, 87-95.

GHS Hazard and Precautionary Statements

Hazard Statements: H361-H303

Suspected of damaging fertility or the unborn child. May be harmful if swallowed.

Precautionary Statements: P201-P281-P202-P312-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2054
Beilstein
3219887
Harmonized Tariff Code
2918.19
TSCA
No
RTECS
FZ1980000

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