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J60364 Chenodeoxycholic acid

CAS Number
474-25-9
Synonyms

Stock No. Size Price ($) Quantity Availability
J60364-06 5g 68.40
J60364-14 25g 210.00
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Chenodeoxycholic acid

MDL
MFCD00064142
EINECS
207-481-8

Chemical Properties

Formula
C24H40O4
Formula Weight
392.57
Form
Needle crystals
Melting point
164-168°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water, dimethyl sulfoxide, ethanol and dimethylformamide.

Applications

Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.

Notes

Incompatible with strong oxidizing agents.

Literature References

Zhang, Y.; Qu, H.; Feng, H.; Wang, X.; Shan, W.; Zeng, W.; Wang, Q.; Zhao, Y. Development of an enzyme-linked immunosorbent assay for chenodeoxycholic acid using an anti-chenodeoxycholic acid monoclonal antibody. Anal. Methods 2015, 7 (11), 4583-4589.

Jones, R. D.; Lopez, A. M.; Tong, E. Y.; Posey, K. S.; Chuang, J. C.; Repa, J. J.; Turley, S. D. Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice. Steroids 2015, 93, 87-95.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2054
Beilstein
3219887
Harmonized Tariff Code
2918.19
TSCA
No
RTECS
FZ1980000

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