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520-18-3 - Kaempferol, 98+% - 3,4',5,7-Tetrahydroxyflavone - J60373 - Alfa Aesar

J60373 Kaempferol, 98+%

CAS Number
520-18-3
Synonyms
3,4',5,7-Tetrahydroxyflavone

Size Price ($) Quantity Availability
50mg 100.12
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Kaempferol, 98+%

MDL
MFCD00016938
EINECS
208-287-6

Chemical Properties

Formula
C15H10O6
Formula Weight
286.24
Form
Powder
Melting point
276-278°
Solubility
Soluble in DMSO or ethanol to 100mM

Applications

Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Keep away fom strong oxidizing agents.

Literature References

Montero et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.  Biochem.J. 2004, 384,( Pt 1), 19-24.

Kang et al. () Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 2009, 611 ,( 1-3), 17-21.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5274
Beilstein
304401
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
LK9275200

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