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A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.
Roelofs, J. Proteasome inhibition by bortezomib: A left hook and a right punch. EBioMedicine 2015, 2 (7), 619-620.
Pantani, L.; Zamagni, E.; Zannetti, B. A.; Pezzi, A.; Tacchetti, P.; Brioli, A.; Mancuso, K.; Perrone, G.; Rocchi, S.; Tosi, P.; Cavo, M. Bortezomib and dexamethasone as salvage therapy in patients with relapsed/refractory multiple myeloma: analysis of long-term clinical outcomes. Ann. Hematol. 2014, 93 (1), 123-128.
Hazard Statements: H301+H311-H330-H372
Toxic if swallowed. Toxic in contact with skin. Fatal if inhaled. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P310-P312-P314-P330-P361-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant