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179324-69-7 - Bortezomib, 99% - MG-341 - J60378 - Alfa Aesar

J60378 Bortezomib, 99%

CAS Number
179324-69-7
Synonyms
MG-341

Size Price ($) Quantity Availability
5mg 126.00
10mg 196.00
25mg 344.00
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Bortezomib, 99%

MDL
MFCD09056737

Chemical Properties

Formula
C19H25BN4O4
Formula Weight
384.24
Form
Powder
Melting point
139-143°
Solubility
Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.

Applications

A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.

Notes

Store in cool place. Keep away from direct sunlight and sources of ignition. Incompatible with strong acids, alkalis, oxidizing and reducing agents.

Literature References

Roelofs, J. Proteasome inhibition by bortezomib: A left hook and a right punch. EBioMedicine 2015, 2 (7), 619-620.

Pantani, L.; Zamagni, E.; Zannetti, B. A.; Pezzi, A.; Tacchetti, P.; Brioli, A.; Mancuso, K.; Perrone, G.; Rocchi, S.; Tosi, P.; Cavo, M. Bortezomib and dexamethasone as salvage therapy in patients with relapsed/refractory multiple myeloma: analysis of long-term clinical outcomes. Ann. Hematol. 2014, 93 (1), 123-128.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330-H372

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes damage to organs through prolonged or repeated exposure.

Precautionary Statements: P260-P284-P301+P310-P304+P340-P320-P330-P361-P302+P350-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1351
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
ED7771666

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