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65391-42-6 - Bestatin hydrochloride, 98% - J60384 - Alfa Aesar

J60384 Bestatin hydrochloride, 98%

CAS Number
65391-42-6
Synonyms

Size Price ($) Quantity Availability
5mg 83.02
25mg 260.00
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Bestatin hydrochloride, 98%

MDL
MFCD00058004

Chemical Properties

Formula
C16H24N2O4•HCl
Formula Weight
344.87
Form
Powder
Melting point
216-218°
Solubility
Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.

Applications

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents.

Literature References

Mei-Rong Jia; Tao Wei; Wen-Fang Xu. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Frontiers in Neuroscience.2010, 4, 50.

Donald L Gardiner; Katharine R Trenholme; Tina S Skinner-Adams; Colin M Stack; John P Dalton. Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. Journal of Biological Chemistry. 2006, 281 (3), 1741-1745.

Other References

Beilstein
4628066
Harmonized Tariff Code
2924.29
TSCA
No

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