Oxonic acid potassium salt is an inhibitor of uricase. This product has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
T Shirasaka; Y Shimamoto; M Fukushima. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Research.1993, 53 (17), 4004-4009.
Yasushi Habu; Ikuko Yano; Masahiro Okuda; Atsushi Fukatsu; Ken-ichi Inui. Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Biochemical Pharmacology. 2005, 69 (6), 993-999.