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Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinases.Doxycycline hydrochloride is an antibiotic used to inhibit matrix metalloproteinases like type 1 collagenase in studies on would healing and tissue remodeling. It shows the broad spectrum antibacterial and antiprotozoan activity. It is often used to treat lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax.
Gad, H. A.; Kamel, A. O.; Sammour, O. A.; Dessouky, H. F. E. Vesicular powder as carrier for doxycycline hydrochloride and metronidazole combination therapy. Pharm. Dev. Technol. 2014, 19 (6), 755-768.
Yang, S.; Li, K. Dissolution profile study on the novel doxycycline hydrochloride sustained-release capsules. Pak. J. Pharm. Sci. 2014, 27 (5), 1615-1620.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.