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10592-13-9 - Doxycycline hydrochloride - J60422 - Alfa Aesar

J60422 Doxycycline hydrochloride

CAS Number
10592-13-9
Synonyms

Size Price ($) Quantity Availability
1g 42.50
5g 74.57
25g 297.67
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Doxycycline hydrochloride

MDL
MFCD03427564
EINECS
234-198-7

Chemical Properties

Formula
C22H24N2O8•HCl
Formula Weight
480.90
Form
Crystalline powder
Melting point
195-201°
Solubility
Soluble in water to 50mg/ml. May require warming.

Applications

Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinases.Doxycycline hydrochloride is an antibiotic used to inhibit matrix metalloproteinases like type 1 collagenase in studies on would healing and tissue remodeling. It shows the broad spectrum antibacterial and antiprotozoan activity. It is often used to treat lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.Incompatible with strong oxidizing agents.

Literature References

Gad, H. A.; Kamel, A. O.; Sammour, O. A.; Dessouky, H. F. E. Vesicular powder as carrier for doxycycline hydrochloride and metronidazole combination therapy. Pharm. Dev. Technol. 2014, 19 (6), 755-768.

Yang, S.; Li, K. Dissolution profile study on the novel doxycycline hydrochloride sustained-release capsules. Pak. J. Pharm. Sci. 2014, 27 (5), 1615-1620.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2941.30
TSCA
No

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