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Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
Yong-Qiang Zhang; Rajini Rao. Global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone. Journal of Biological Chemistry. 2007, 282, (52), 37844-37853.
Minhui Wang; Jiaojiao Shan; Qian Yang; Xianglei Ma; Sisi Jin; Xiaoke Guo; Qidong You; Yiqun Tang. Antiarrhythmic efficacy of CPUY102122, a multiple ion channel blocker, on rabbits with ischemia/reperfusion injury. Pharmacological reports : PR.2014, 66, (6), 1022-1030.
Hazard Statements: H312+H332-H361d-H373
Harmful in contact with skin. Harmful if inhaled. Suspected of damaging the unborn child. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P201-P202-P260-P271-P281-P302+P352-P304+P340-P308+P313-P312-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant