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117591-20-5 - Calpeptin, 98+% - N-Benzyloxycarbonyl-L-leucyl-norleucinal - Z-Leu-norleucinal - J60481 - Alfa Aesar

J60481 Calpeptin, 98+%

CAS Number
117591-20-5
Synonyms
N-Benzyloxycarbonyl-L-leucyl-norleucinal
Z-Leu-norleucinal

Size Price ($) Quantity Availability
10mg 103.19
50mg 417.09
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Calpeptin, 98+%

MDL
MFCD00155623

Chemical Properties

Formula
C20H30N2O4
Formula Weight
362.50
Form
Powder
Solubility
Soluble in DMSO at 15mg/ml

Applications

Calpeptin is used to to inhibit the activities of cathepsin L and calpain-1. Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. It acts as an inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. It is shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Store with desiccant. Keep away fom strong oxidizing agents.

Literature References

Tsujinaka et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun.  1988, 153  ,(3), 1201-8.

Sasaki et al. Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 1990, 3 ,(3), 195-201.

Other References

Harmonized Tariff Code
2924.19
TSCA
No

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