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J60489 Niflumic acid, 99+%

CAS Number
4394-00-7
Synonyms
2-[3-(Trifluoromethyl)anilino]nicotinic acid
2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid

Stock No. Size Price ($) Quantity Availability
J60489-06 5g 40.30
J60489-09 10g 68.00
J60489-18 50g 281.00
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Niflumic acid, 99+%

MDL
MFCD00010569
EINECS
224-516-2

Chemical Properties

Formula
C13H9F3N2O2
Formula Weight
282.22
Form
Crystalline powder
Melting point
203-204°
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml).

Applications

It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Hygroscopic. Keep away fom strong oxidizing agents.

Literature References

Ottolia .; Toro. Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J.  1994, 67 ,(6), 2272-9.

Famaey. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 1997, 46 ,(11), 437-46.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H332-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,6531
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
QT2999100

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