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Kemptide, phosphate acceptor, is shown to be a basic serine-containing heptapeptide corresponding to a sequence from pig liver pyruvate kinase. This synthetic peptide is a substrate of PKA (cyclic AMP-dependent protein kinase) and is phosphorylated and activated after microinjection into Xenopus oocytes. Exposure of Kemptide to insulin has demonstrated an increase in activation of this agent, which can be inhibited by the catalytic subunit of phosphatase 2A.
Mark A. Giembycz.; Jack Diamond. Evaluation of Kemptide, a synthetic serinecontaining heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues. Biochem. Pharmacol. 1990, 2 (39),271-283 .
Shawna M. Hengel.; Scott A. Shaffe.; Brook L. Nunn.; David R. Goodlett. Tandem Mass Spectrometry Investigation of ADP-ribosylated Kemptide.J. Am. Soc. Mass. Spectrom. 2009, 20 (3),477-483 .