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65189-71-1 - Kemptide - Phosphate acceptor peptide - Leu-Arg-Arg-Ala-Ser-Leu-Gly - J60591 - Alfa Aesar

J60591 Kemptide

CAS Number
65189-71-1
Synonyms
Phosphate acceptor peptide
Leu-Arg-Arg-Ala-Ser-Leu-Gly

Size Price ($) Quantity Availability
1mg 43.20
5mg 135.00
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Kemptide

MDL
MFCD00076710

Chemical Properties

Formula
C32H61N13O9
Formula Weight
771.91
Form
Powder
Solubility
Soluble in water (20 mg/ml).

Applications

Kemptide, phosphate acceptor, is shown to be a basic serine-containing heptapeptide corresponding to a sequence from pig liver pyruvate kinase. This synthetic peptide is a substrate of PKA (cyclic AMP-dependent protein kinase) and is phosphorylated and activated after microinjection into Xenopus oocytes. Exposure of Kemptide to insulin has demonstrated an increase in activation of this agent, which can be inhibited by the catalytic subunit of phosphatase 2A.

Notes

Store at -20°C. Protect from heat. Incompatible with oxidizing agents.

Literature References

Mark A. Giembycz.; Jack Diamond. Evaluation of Kemptide, a synthetic serinecontaining heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues. Biochem. Pharmacol. 1990, 2 (39),271-283 .

Shawna M. Hengel.; Scott A. Shaffe.; Brook L. Nunn.; David R. Goodlett. Tandem Mass Spectrometry Investigation of ADP-ribosylated Kemptide.J. Am. Soc. Mass. Spectrom. 2009, 20 (3),477-483 .

Other References

Beilstein
6263936
Harmonized Tariff Code
2925.29
TSCA
No

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